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Are willing and able to complete the scheduled study assessments, including endoscopy and daily diary entry. If female, must meet the contraception requirements. Participants with evidence of colonic dysplasia or have been diagnosed with cancer of the gastrointestinal tract during study AMAN NCT Participants with certain laboratory abnormalities prior to start of AMBG that would require permanent discontinuation from study drug.

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If female, must meet the contraception requirements.

Participants with escors laboratory abnormalities prior to start of AMBG that would require permanent discontinuation from study drug. Participants with evidence of colonic dysplasia or have been diagnosed with cancer of the gastrointestinal tract during study AMAN NCT Are willing and able to complete the scheduled study assessments, including endoscopy and daily diary entry.